TY - JOUR AU - Tsige , Yeterefwork AU - Gelaw, Baye AU - Alemayhu, Marta AU - Amsalu, Anteneh PY - 2017/09/10 Y2 - 2024/03/28 TI - The Prevalence Of Methicilin Resistant Staphylococcus Aureus And Associated Risk Factors Among Patients With Wound Infection At Dessie Referral Hospital, Northeast Ethiopia JF - Ethiopian Journal of Health and Biomedical Sciences JA - Ethiop J Health Biomed Sci VL - 8 IS - 1 SE - Orginal Articles DO - 10.20372/ejhbs.v8i1.280 UR - https://journal.uog.edu.et/index.php/EJHBS/article/view/280 SP - 15-30 AB - <p><strong><em>Back ground: </em></strong><em>The emergence of</em> <em>Methicilin resistant</em><em> Staphylococcus aureus (MRSA) has posed serious therapeutic challenges globally. </em><em>The aim of this study was to determine the prevalence of MRSA infection and related risk factors among patients suffering from wound infection.</em></p><p><strong><em>Materials and Methods:</em></strong><em> A hospital based cross-sectional study was conducted among patients suffering from wound infection. </em><em>Socio-demographic characteristics and potential risk factors were assessed using a pre-tested and structured questionnaire</em><em>. Wound swabs were collected following Levine’s technique and deposited in a tube that had brain heart infusion. Each wound specimen was inoculated on Blood agar plate (BAP), MacConkey agar (MAC), and Mannitol salt agar (MSA) then incubated at 37</em><em><sup>O</sup></em><em>C for 24 hrs. S. aureus suspected colonies were identified using standard laboratory procedures and MRSA was </em><em>determined based on the resistance pattern of cefoxitin. </em></p><p><strong><em>Results</em></strong><em>: A total of 266 wound swabs were investigated and </em><em>66.2% were found positive for bacterial pathogens.</em><em> The overall prevalence of S. aureus was </em><em>34.6%. </em><em>The prevalence of MRSA infection was 28.3% (26/92) and that of Methicilin sensitive Staphylococcus aureus (MSSA) was 71.7% (66/92). All </em><em>MRSA isolates were resistant to </em><em>penicillin. On the other hand, 61.5% of the MRSA isolates were resistant to erythromycin and ciprofloxacin </em><em>and </em><em>53.8% for cotrimoxazole and gentamicin. However, </em><em>MRSA isolates demonstrated lower resistance to clindamycin (7.7%). Data also showed that 69.8% of the MRSA isolates </em><em>showed multidrug resistance, but MDR among MSSA isolates were only 3%. Hospital admission (P = 0.006), Low BMI (P&lt;0.001) and&nbsp; farming occupation (P = 0.040) were the risk factors significantly associated with wound infection due to MRSA.</em></p><p><strong><em>Conclusion: </em></strong><em>The prevalence of S. aureus</em><em> infection was high, and a significant proportion of the isolates were Methicilin resistant. The occurrence of MRSA among patients with wound infection indicates a need for regular investigation of wound samples by culture and drug susceptibility testing.&nbsp; </em></p><p>&nbsp;</p> ER -