Selective Synthesis and Biological Application of Flavonoids
Keywords:Flavonoids, Isoflavonoids, Neoflavonoids, Flavone
Secondary metabolites such as alkaloids, polyphenols, and isoprenoids are produced by plants. From these, flavonoids are one of the most naturally found polyphenol organic compounds. Flavonoids have a wide range of biological uses such as anti-diabetic activity and anti-cancer activity as well as antioxidant properties. This review article presents the various chemical synthetic methods of flavonoids. Flavonoids are prepared from chalcones, coumarin, 1,3-diones, eugenol using cyclic oxidation, Wacker oxidation, Suzuki-Miyaura reaction, and Knoevenagel condensation. Flavonoids can be divided into three main classes such as flavones, isoflavonoids and neoflavonoids (4-arylcoumarins). Flavones are successfully synthesized by Baker and Venkatraman synthesis and Claisen-Schmidt condensation method while Isoflavonoids are prepared using deoxybenzoin, Suzuki-reaction, oxidative rearrengement, and chalcone routes. Neoflavonoids are synthesized from coumarin using Suzuki-Miyaura reaction and Knoevenagel condensation system.
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