Recent Advances in Synthesis of Coumarins: Coumarin Derivatives and Their Biological Application

Authors

  • Gamachu Fikadu Mettu University
  • Kibur Hunie University of Gondar

Keywords:

Coumarin, synthesis; coumarin derivatives; conventional method, nonconventional method

Abstract

Coumarin was first extracted from Tonka bean by Vogel in 1820. Coumarin and its derivatives
are important groups of compounds due to their medicinal and pharmacological properties. These
compounds have a significant role in the development of new drugs. Many different
conventional methods and non-conventional methods have been developed to synthesize
coumarin derivatives. The objective of this review paper is to present the various methods of
coumarin synthesis, both conventional and green synthesis. Techniques such as heating,
microwave, and ultrasound irradiation were employed. Moreover, various solvents and catalysts
were employed in order to obtain better yields. The present review revealed that the conventional
methods are time-consuming, environmentally polluting, and lower in yield whereas the green
synthesis of coumarin derivatives is better in yield, environmentally eco-friendly and rapid. This
review summarized several conventional methods, non-conventional methods and reaction
conditions for the synthesis of coumarin derivatives from various precursors such as aldehydes,
carboxylic acids, ketones and phenols. Literature collection was conducted using various search
engines.

Additional Files

Published

2023-01-18